U.S., Jan. 18 -- ClinicalTrials.gov registry received information related to the study (NCT03801629) titled 'Neuroimmune Effects of Opioid Administration' on Jan. 8.
Brief Summary: In this study, a novel human laboratory model will be evaluated. Acute opioid-induced neuroimmune responses will be quantified among healthy volunteers (Specific Aim). To measure the neuroimmune system, we will use [11C]PBR28 positron emission tomography (PET) imaging to quantify 18kDa translocator protein (TSPO) levels. TSPO is an imaging marker of the neuroimmune system thought to reflect microglia levels. Up to twenty healthy volunteers will complete two 120-minute [11C]PBR28 PET scans. One scan will take place prior to a single morphine administration (0.07 ...