IISc designs antigen to boost production of antibodies against cancer cells
India, April 23 -- Researchers at the Indian Institute of Science (IISc) in Bengaluru have designed a synthetic compound (antigen) that can latch on to a protein in blood and hitchhike a ride to the lymph node, where it can boost the production of antibodies against cancer cells.
The approach gives a new direction to develop vaccine candidates for a variety of cancers, the researchers say.
Inside the human body, cancer cells can weaken or shut down the production of antibodies that target and eliminate them. Developing a cancer vaccine, therefore, involves modifying or creating a mimic of an antigen found on the surface of cancer cells to turn up or turn on this antibody production. In recent years, scientists have turned to carbohydrat...
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